Traditionally, multiple factors such as histological subtype, G3 histology, myometrial invasion ≥50%, lymphovascular space invasion (LVSI), lymph node metastases, tumor diameter >2 cm, and presence of L1 cell adhesion molecule (L1CAM = CD171) have been identified as conferring high risk for recurrent disease (26). This evidence concerns the gene L1CAM and neoplasm.