There are also some shortcomings, firstly, this study used summary statistics rather than raw data in the analysis process, in this study, it can only reflect the promotional effect of Apo B on oral leukoplakia, and suggests a suggestive promotional effect of cholesterol, triglycerides, and low-density cholesterol on the development of oral leukoplakia, and a suggestive protective effect of non-albumin proteinuria on the development of oral leukoplakia However, the mechanisms involved in how they contribute to the development of oral leukoplakia have not been further explored. The gene discussed is APOB; the disease is Oral leukoplakia.