APOB and Oral leukoplakia: biomarkers had a promotional effect on oral leukoplakia: Apolipoprotein B (OR = 1.66, 95% CI: 1.29-2.19, P= 0.00034), Cholesterol (OR = 1.51, 95% CI: 1.13-2.02, P=0.00530), Low-density Lipoprotein, LDL (OR = 1.55, 95% CI: 1.16-2.06, P= 0.00308), Triglycerides (OR = 1.38, 95% CI: 1.01-1.87, P= 0.04158), and one of the biomarkers played a protective role against oral leukoplakia: Non Albumin Protein (OR = 0.67, 95% CI: 0.47-0.97, P= 0.03504).