After Bonferroni correction the protective effect of Apolipoprotein B remained significant Apolipoprotein B [OR = 1.66, 95% CI: 1.29-2.19, P= 0.00034 (PBonferroni<0.0007)], however the remaining 5 biomarkers when tested by IVW suggested correlations with oral leukoplakia, but after Bonferroni correction these correlations were no longer significant, but still suggested some predisposition for oral leukoplakia (0.05<P<0.0007). The gene discussed is APOB; the disease is Oral leukoplakia.