Increased lipid requirements to meet the needs of these proliferating cells are expected to reduce existing lipid stores (hypocholesterolemia), low levels of lipids may be due to rapid cell division during neomembrane biogenesis as precancerous cells and malignant tumors utilize them (21, 22), and changes in these biomarkers in addition to Apo B may be risk factors for leukoplakia or suggestive of oral cancer development, and some study found elevated serum β2-microglobulin levels in oral cancer and potentially malignant diseases of the oral cavity, possibly (23, 24). The gene discussed is APOB; the disease is Hypocholesterolemia.