It is a member of the carcinoembryonic antigen (CEA) family whose members are known to play a role in cell adhesion.22 Specifically, CEACAM6 expression has been reported in granulocytes and lung and intestinal epithelial cells.23 In ileal epithelial cells of patients with Crohn’s disease, CEACAM6 has been found to act as a receptor for adherent-invasiveEscherichia coli.24 It has also been found to mediate entry ofNeisseria gonorrhoeae.25 CEA family members are widely used as tumor markers in serum as well as tumor immunoassays. The gene discussed is CEACAM5; the disease is Crohn disease.