In a recent survey, 0.49% of the U.S. population reported a current sesame allergy, whereas 0.23% met symptom-report criteria for IgE-mediated allergy. Among individuals with verified IgE-mediated sesame allergy, an estimated 23.6% to 37.2% had previously experienced a severe allergic reaction, depending on the definition used. Other surveys estimated the prevalence in the range of 0.1–0.2% in the USA and Western Europe, and as high as 0.8–0.9% in the Middle East and other regions where sesame seeds are widely consumed. This evidence concerns the gene IGHE and allergic disease.