LMNA and familial dilated cardiomyopathy: Non-ischaemic dilated cardiomyopathy (DCM) is estimated to occur in approximately 1:250, and of those, approximately 30–50% are assumed to be familial.1 Lamin A/C (LMNA) gene mutations are a known cause of familial DCM, conveying a high risk of sudden cardiac death (SCD) at an estimated rate as high as 46%.2 In a retrospective study of 49 families of patients with DCM in Colorado, USA, and Italy, carriers of an LMNA mutation were more likely to be younger (22–32 years old) than non-carriers at the time of diagnosis.