Macrophage exosomes overexpressing recombination signal binding proteinJκ (RBPJ) overexpress hsa_circ_0004658, which led to the upregulation of junctional adhesion molecule 3 through the adsorption of miR‐499b‐5p, thereby inhibiting HCC cell proliferation and promoting apoptosis, suggesting the diagnostic and therapeutic potential of hsa_circ_0004658 as a biomarker and target for HCC cell therapy.692. The gene discussed is RBPJ; the disease is hepatocellular carcinoma.