The hypoxic CRC cell‐derived exosome circ‐133 is able to translocate to normal tumor cells and promote migration via the miR‐133a/guanine nucleotide exchange factor‐H1 (GEF‐H1)/RhoA axis, suggesting a difference in metastatic potential between hypoxic and relatively normoxic cancer cells.711. The gene discussed is RHOA; the disease is neoplasm.