Moreover, CircEDIL3 originating from SMSCs‐Exos effectively suppresses inflammation‐induced angiogenesis and promotes pannus progression, both in vitro and in vivo, via the miR‐485‐3p/PIAS3/STAT3/VEGF functional module, ultimately ameliorating RA.482. This evidence concerns the gene PIAS3 and rheumatoid arthritis.