For example, the plasma exosome circLPAR1 can be internalized by CRC cells and inhibits METTL3–eukaryotic translation initiation factor 3 subunit h (eIF3h) through binding to eIF3h, thereby inhibiting mRNA translation, which in turn inhibits the expression of the oncogene bromodomain‐containing protein 4 (BRD4), thereby suppressing CRC cell proliferation, invasion and migration. This evidence concerns the gene BRD4 and colorectal carcinoma.