CircEPB41L2 acts as a sponge for miR‐215p and miR‐9425p in exosomes, and overexpression of circEPB41L2 inhibits CRC cell proliferation, enhances apoptosis, and inhibits migration and invasion, which subsequently blocks the regulation of PTEN/AKT signaling pathway by these two miRNAs, ultimately presenting an inhibitory effect on CRC progression in cells and animal models.716. This evidence concerns the gene PTEN and colorectal carcinoma.