Overexpression of circ‐IARS significantly downregulated miR‐122 and zonula occludens‐1 (ZO‐1) levels, upregulated RhoA and RhoA‐GTP levels, increased filamentous actin (F‐actin) expression and adhesive plaques, and increased endothelial monolayer permeability to promote tumor invasion and metastasis.633. The gene discussed is RHOA; the disease is neoplasm.