This process enhances tripartite motif containing 59 (TRIM59) phosphorylation, thereby increasing TRIM59 binding to signal transducer and activator of transcription 3 (STAT3) and promoting STAT3 phosphorylation, which ultimately leads to cardiomyocyte proliferation, potentially providing a therapeutic target for cardiac repair after MI.418. Here, STAT3 is linked to myocardial infarction.