PRKCH and psychiatric disorder: We identified dysregulations in four PKC genes—PRKCA, PRKCB, PRKCH, and PRKCI—known for their roles in mood regulation and stress response, crucial for neurodevelopment and linked to psychiatric disorders (Choi et al., 2011; Coon et al., 2020; Sokolowski and Wasserman, 2020; Pandey et al., 2021).