,10 ARV has been proven to exhibit potent anticancer activity as a single agent or in combination with other tumor targeting small molecules in VEM-resistant melanoma cell lines in vitro.11,12 Therefore, we aimed to investigate the antitumor potential of ARV by further combining it with other therapeutic modality to synergistically target oncogenic c-Myc expression in drug-resistant melanoma. The gene discussed is MYC; the disease is neoplasm.