Importantly, we were able to target critical cellular signaling pathways by significantly upregulating levels of PTEN expression while decreasing the levels of BRD4 and pMAPK/MAPK expression to ultimately gain inhibition of oncogenic c-Myc expression following combinatorial therapy of PL-NANO and AL-NANO in BRAFi-resistant melanoma cells. The gene discussed is BRD4; the disease is melanoma.