With the progress of molecular biology and bioinformatics, current understandings of AQP4-related and MOG-related optic neuritis have transcended the realm of autoantibody discovery, advancing into the molecular mechanisms and the realm of epigenetics (Carnero Contentti and Correale, 2021; Mehmood et al., 2023). This evidence concerns the gene AQP4 and optic neuritis.