Abbreviations: AST = aspartate aminotransferase; ALT = alanine aminotransferase; γ-GTP = γ-glutamyl transpeptidase; LDH = lactate dehydrogenase; BUN = blood urea nitrogen; eGFR = estimated glomerular filtration rate; BNP = brain natriuretic peptide; LVDd = left ventricular end-diastolic diameter; LVDs = left ventricular end-systolic diameter; HFrEF = heart failure with reduced ejection fraction. The gene discussed is NPPB; the disease is heart failure.