Abbreviations: BMI = body mass index; BW = body wight; HF = heart failure; ICM = ischemic cardiomyopathy; BP = blood pressure; NYHA = New York Heart Association; HD = hemodialysis; PD = peritoneal dialysis; ACE-I = angiotensin-converting enzyme inhibitor; ARB = angiotensin 2 receptor blocker; MRA = mineralocorticoid receptor antagonist; CCB = calcium channel blocker; DPP-4 I = dipeptidyl peptidase-4 inhibitor; SGLT-2 I = sodium glucose cotransporter-2 inhibitor; DOAC = direct oral anticoagulants. The gene discussed is DPP4; the disease is ischemic cardiomyopathy.