CD274 and neoplasm: dSUVmax, dSUVmean, eSUVmax, eSUVmean, ΔSUVmax, ΔSUVmean, and ΔTLG were significantly higher in patients with positive PD-L1. High glucose metabolism on dual-time-point 18F-FDG PET correlated with the tumor microenvironment immune types-I tumors.