The combination AI model showed a high-performance with AUCs of 0.95, 0.934, and 0.946 for predicting PD-L1 expression signature <1%, 1-49%, and ≥50%, respectively. The combination AI model was trained on multi-source features the performance of OS evaluation in NSCLC patients (C-index: 0.89). Here, CD274 is linked to non-small cell lung carcinoma.