RT-qPCR results showed that overexpression of AQP1 significantly attenuated the levels of mRNA of NGAL and KIM-1 in renal tissues of septic AKI rats, while up-regulation of P53 expression by Kevetrin hydrochloride (Keve, a P53 agonist) restored the gene levels of NGAL and KIM-1 (Figure 7B). Here, TP53 is linked to acute kidney injury.