In the animal experiments, we established an AKI model by intraperitoneal injection of LPS and found that AQP1 protein expression was increased in kidney tissues and serum of rats at 8 h after LPS treatment and peaked at 12 h, then decreased at 24 h and reached the lowest level at 7 d (Figures 4A, D). The gene discussed is AQP1; the disease is acute kidney injury.