INS and metabolic syndrome: 1.Inhibited PTP1B mRNA and protein expression in monkey hepatocytes2.Reduced PTP1B mRNA expression in liver/adipose tissues in monkeys3.Increased adiponectin concentrations & lowered insulin responses in monkeys4.Improved insulin sensitivity & normalized plasma glucose levels in mice and monkeys5.Downregulated lipogenic genes within fat and liver as well as adipocyte differentiation associated genes in fat tissue of mice6.Tolerated and safe in people, improved dyslipidemia & increased adiponectin, decreased body weight