The stimulation secretion coupling of the two incretin hormones, i.e., glucagon‐like peptide‐1 (GLP‐1) and glucose‐dependent insulinotropic polypeptide (GIP), secreted by the enteroendocrine cells (EECs) of the intestines, is well known to be affected by metabolic disease [11]. This evidence concerns the gene GCG and metabolic disease.