Univariate analysis of factors revealed that 16 variables, including age, education level, employment, monthly household income, living arrangements, dialysis vintage, dry weight, inter-dialysis weight gain, actual ultrafiltration, parathyroid hormone, hemoglobin, C-reactive protein, anxiety, depression, insomnia, and social support, were associated with fatigue in HD patients (Table 2). The gene discussed is CRP; the disease is major depressive disorder.