Based on these accumulating evidence and results, we therefore presumed that DJ‐1 had same merits in EBI caused by SAH via regulating Akt/Nrf2 signaling pathway, for kindred mechanisms play similar roles in multiple neurological diseases, and subsequently initiated our study utilizing betulin to explore its impact on DJ‐1 and the possible effect on Akt/Nrf2 signaling pathway and the outcome of SAH. Here, NFE2L2 is linked to nervous system disorder.