We further performed immunohistochemical and Western blot analyses revealing a marked decrease in tumor GRP78 protein levels upon OLN treatment (Fig. 6D, E, and S5A), coinciding with significantly elevated levels of cleaved PARP, caspase-3, and caspase-7, indicative of enhanced apoptosis (Fig. 6E). The gene discussed is CASP3; the disease is neoplasm.