TSPO and amyloidosis: Building upon the variably elevated microglial tracer uptake per cell, microglia showed a reduced correlation of the TSPO uptake between forebrain and hindbrain in presence of amyloidosis (Z = 1.33 in WT versus Z = 0.93 in AppNL−G−F) and thus reduced forebrain-hindbrain synchronicity (Fig. 11D).