This study further evaluated the gastrointestinal mucosal expression of canine calprotectin, the S100A8/A9 protein complex, and compared calprotectin concentrations in the supernatants of mucosa extracts from dogs with CIE to those from healthy Beagles and to the severity of clinical signs, clinicopathologic findings, histologic lesions, and clinical outcomes. The gene discussed is IGKV1D-22; the disease is congenital non-bullous ichthyosiform erythroderma.