CXCL8 and ischemia: In addition, leukotriene B4 (LTB4), cytokine-induced neutrophil chemoattractant 1 (CINC-1), macrophage inflammatory protein-2α (MIP-2α), complement 5a, IL-8 and CXCL8 amplifies recruitment of neutrophils to infiltrate in damaged area after the onset of ischemia which further leads to overproduction of ROS and releases granular components composed of proteases and myeloperoxidase, to remove apoptotic bodies as well as necrotic debris.