ACE and myocardial ischemia: However, among different pretreatment methods such as the pharmacological intervention of beta-blockers, antiplatelets drugs, angiotensin-converting enzyme (ACE) inhibitors, fibrinolytic, calcium channel blockers (CCB), nitrates, cholesterol-lowering agents, exercise, and hypoxia, ischemic pretreatment (IP) has been proved to be the effective protective mechanisms because of its application in the prevention of primary and secondary prophylaxis of IHD [7].