For instance, it has been reported that HDAC10 can combine with Pax3 and KAP1 to form a ternary complex and inhibit their expression and activity to promote melanogenesis, and only HDAC10 expression levels significantly correlate with poor overall survival in neuroblastoma patients among the 11 metal-dependent HDACs [43]. The gene discussed is PAX3; the disease is neuroblastoma.