To elucidate the biological effects of HDAC10 in ccRCC, we initially assessed the expression of HDAC10 in five ccRCC cell lines, including 786-O, OSRC2, A498, SN12-PM6 and Caki-1, through qPCR and western blot experiments (Supplementary Fig. 2A-B). This evidence concerns the gene HDAC10 and nonpapillary renal cell carcinoma.