Based on six biological markers measured at diagnosis from 14,755 diabetic patients, Ahlqvist et al. [62] proposed redefining T1D and T2D into five novel subgroups characterized by the time of onset (early vs. late), body mass index (low vs. high), metabolic control (poor vs. moderate) and insulin production (deficient vs. resistant). Here, INS is linked to type 2 diabetes mellitus.