Intriguingly, IKZF4 has been shown to be necessary for the inhibitory role of T-regulatory cells [149, 150], suggesting rs1689510 may regulate the predicted expression levels of several genes involved in immune function, including IKZF4 and GDF11. Overall, these results encourage future studies on the role rs1689510 plays in the immune system and disease progression and development, particularly asthma. The gene discussed is IKZF4; the disease is asthma.