Moreover, other genes associated exclusively with FTD are implicated in lysosomal trafficking, including TMEM106B and the major facilitator superfamily domain containing 8 (MFSD8) or in lysosomal activity, such as Cathepsin F (Ctsf) and granulin precursor (GRN) [190–193]. This evidence concerns the gene MFSD8 and frontotemporal dementia.