Transwell and scratch assays showed that overexpression of Lin28a partially reversed the inhibitory effect of hsa_circ_0000520 on cell migration and invasion, while knockdown of Lin28a partially inhibited the enhanced invasiveness of bladder cancer caused by hsa_circ_0000520 knockdown (Supplementary Fig. 3A–D). The gene discussed is LIN28A; the disease is urinary bladder carcinoma.