Tumor cells with hypoxia‐induced EMT phenotype were enriched in PT and MLN, which is consistent with previous study reporting that EMT transition of tumor cells can be induced by the hypoxic environment of the primary tumor, resulting in distant metastasis.[48] We also found that tumor cells with high KRAS signal expression increased from PT to MLN, and their high expression of CXCR4 was associated with directional chemotaxis and metastasis of tumor cells to lymph nodes.[49] Tumor heterogeneity is an important reason for the failure of targeted drug therapy. The gene discussed is CXCR4; the disease is neoplasm.