ESR1 and neoplasm: These findings are consistent with previous reports that highlight the functional interaction between EMT‐associated transcription factors and estrogen receptor α (ERα), which leads to the transformation of epithelial‐like cells into mesenchymal cells and promotes distant metastasis.[9–11] In summary, our results revealed epithelial cell subtypes exhibit different gene expression programs, and are associated with preference for lymph node metastasis of tumor cells.