ERN1 and neoplasm: CXCL5 and CXCL8 can combine with CXCR2 on tumor cells and vascular endothelial cells to promote tumor metastasis and angiogenesis.[25‐27] TAMs‐derived EREG acts as a ligand for EGFR and is associated with tumor invasion.[28] What's more, ERN1 is thought to be associated with the polarization of TAMs toward the M2 phenotype.[29] These genes were enriched in wound healing, angiogenesis, and negative regulation leukocyte activation pathways.