CD226 and neoplasm: TAMs remodel the extracellular matrix by secreting FN1 (fibronectin‐1), binds to integrin receptors on the lymphocyte membrane, and limits its contact with tumor cells to avert T cell‐mediated tumor elimination.[36,37] CD155, as an immunosuppressive molecule, can bind to the co‐stimulatory receptor CD226 and TNFSF9 on the surface of CD8+ T cell membrane to disable it[38,39] (Figure 6C).