The heterogeneous function of tumor‐associated macrophages in tumor initiation, progression, and metastasis have been extensively studied in primary TME of various cancer types (e.g., colorectal, lung, and liver cancers).[53‐56] Studies have shown that SPP1+ macrophages are thought to play pro‐angiogenic and matrix‐remodeling functions in primary tumors,[54,55] but remains unclear in lymph node metastatic microenvironment. This evidence concerns the gene SPP1 and liver cancer.