We previously identified the combination of transcription factors composed by PU.1, IRF8, and BATF3 (PIB) as sufficient to reprogram fibroblasts or tumor cells into cDC1-like cells in vitro endowed with the three signals required to activate T cells, including antigen presentation on MHC class I and II, co-stimulatory molecule expression and chemokine/cytokine secretion (21–23). The gene discussed is IRF8; the disease is neoplasm.