When compared with natural 2D cultures, reprogrammed cells in spheroids showed higher levels of transcriptional affiliation to cDC1s and rapid activation of the tumor-APC gene signature by day 3, which was previously established using commonly up-regulated cDC1 genes during reprogramming of 18 human cancer cell lines (23) (Fig. 5, F and G). Here, MPPE1 is linked to cancer.