CD4 and neoplasm: Next, we profiled lymphoid populations in tumor-draining lymph nodes (tdLN) and observed expansion of CD4+ T cells (eGFP 23.6 ± 2.3% vs. PIB-eGFP 29.0 ± 4.9%), while no major changes in CD8+ T, B and NK cells were observed (Fig. 2L and fig.