IL1R1 and cancer: Finally, as our study elucidated the role of the IL-1α/IL-1R1 axis in aging-driven emergency myelopoiesis during the progression of colorectal and pancreatic cancer, we suspect that this mode of pathogenic myelopoiesis is active during the growth of other solid tumors and propose that the blockade of IL-1R1 signaling will likely also be therapeutic in different cancer settings.