Moreover, because CHIP is linked to various chronic inflammatory conditions (e.g., cardiovascular disease, chronic kidney disease, arthritis, cirrhosis) (111–116) that would likely further polarize bone marrow and promote myelopoiesis, targeting pathways that link CHIP with lung cancer would effectively ameliorate the pro-tumorigenic contributions of these co-morbidities. Here, STUB1 is linked to Cirrhosis.