EZH2 and thyroid gland undifferentiated (anaplastic) carcinoma: In the context of anaplastic thyroid carcinoma (ATC), the inhibition of EZH2 has been demonstrated to suppress Wnt/β-catenin signalling, thereby contributing to its oncogenic role, with targeting EZH2 resulting in reduced β-catenin activity and consequential effects on proliferation and invasion [134].