The unique upregulation of H3K27me3 by the PRC2 complex in Ov-CCA, notably involving EZH2 and SUZ12 compared to other cancers, signifies a specific epigenetic mechanism contributing to its aggressiveness, potentially making histone-modifying enzymes like EZH2 viable targets for treatment and prognosis evaluation [99]. Here, SUZ12 is linked to cholangiocarcinoma.