In chemoresistant Head and Neck Squamous Cell Carcinoma (HNSCC) cells, both the Wnt/β-catenin pathway and EZH2 are upregulated, indicating a relationship between higher EZH2 expression and Wnt/β-catenin pathway activation, contributing to chemoresistance and cancer stem cell accumulation [136]. This evidence concerns the gene EZH2 and cancer.