ATF4 and Alzheimer disease: For example, our analysis correctly identified two well-known transcriptional regulators of AD, KDM5A [40] and ATF4 [41]–but only the mRNA expression level of KDM5A showed a high correlation with the mean expression of its regulon (R2 = 0.85) (Fig 3C) while ATF4 did not (R2 = 0.40) (Fig 3D).