Daily intraperitoneal injection of 100 μg/kg LPS for 2 weeks in Zucker rats fed a diet rich in disaccharides led to decreased plasma adiponectin levels, increased plasma leptin levels, and increased hepatic steatosis alongside increased markers of liver lipogenesis and inflammation indicative of metabolic dysfunction-associated fatty liver disease (MAFLD) (23). The gene discussed is ADIPOQ; the disease is fatty liver disease.