In this study, we found that the downregulation of CASZ1 in ccRCC may be explained by certain DNA methylation statuses, including hypermethylation of cg18236877, cg10053369, cg24293689, cg09179249, cg04896832, cg00925802, cg11222217, cg22853713, cg11732134, cg18271964, cg23670372, cg16926809, and cg17158913. Here, CASZ1 is linked to nonpapillary renal cell carcinoma.