Through the use of immunohistochemical staining, it was possible to determine that, although CASZ1 protein was undetectable in all 12 of the ccRCC tumor tissues, it was visible in the membrane, cytoplasm, and nucleus of the renal tubules in each of the three normal tissues with moderate intensity and 75–25% quantity (Fig. 1C). This evidence concerns the gene CASZ1 and neoplasm.