Wolf et al. suggested three mechanisms linking T2D with breast cancer: activation of the insulin pathway, activation of the insulin-like-growth-factor (IGF) pathway, and regulation of endogenous sex hormones caused by increased production of oestradiol and androgens combined with decreased liver production of sex hormone binding globulin (SHBG), [11, 12]. Here, SHBG is linked to type 2 diabetes mellitus.