While the INO80-related CRC SWR1 replaces H2A-H2B dimers in nucleosomes with H2A.Z-H2B, INO80 can inversely exchange H2A.Z-H2B with free H2A-H2B (Papamichos-Chronakis et al. 2011). The gene discussed is INO80; the disease is colorectal carcinoma.