PIK3CA and pulmonary embolism: Of note, personal history in some patients with PIK3CA mutated EC encompasses (1) the presence of vascular malformations, including brain vessel aneurysm and frequent clinically advanced varices of lower extremities treated by surgical intervention, and (2) major thrombotic events, including significant pulmonary embolism and thrombosis of the mesenteric artery with intestinal hemorrhagic necrosis and death of the patient (Table 2).