Splicing factor (SF3B1 SRSF2, and U2AF1) mutations are the most common mutations in MDS (Haferlach et al., 2014; Papaemmanuil et al., 2011; Papaemmanuil et al., 2013; Yoshida et al., 2011). The gene discussed is SLU7; the disease is myelodysplastic syndrome.