TNF and cancer: Interestingly, we found upregulation of inflammatory, Interferons, TNFA, and JAK-STAT signalling pathways within cancer hallmark gene sets (Figure 2—figure supplement 4a) and upregulation of chemokines and Neutrophils amongst Reactome gene sets (Figure 2—figure supplement 4b) supporting the trend observed by MOFA (Figure 2d and Figure 2—figure supplement 3b).