The main strengths of our approach include the use of widely implemented flow cytometry markers and accurate exclusion of T‐cell lymphomas, which could present with large CD30 positive cells in deep lymph nodes, especially anaplastic large cell lymphoma, angioimmunoblastic T‐cell lymphoma, and peripheral T‐cell lymphoma not otherwise specified. This evidence concerns the gene TNFRSF8 and anaplastic large cell lymphoma.