MAPT and Alzheimer disease: We observed that the rate of change in tOC was associated with amyloid and tau PET SUVR (Figure 6C,6D), in line with previous associations of amyloid and tau with neuroanatomical changes in AD,41, 42, 43, 44 although it is important to note that the amyloid/tau/neurodegeneration (ATN) interplay is likely to differ from individual to individual.45, 46