Moreover, we found that age, sex, total MMSE score and AD stage (AC score), and APOE ε4 status were not associated with either having or not having a marked rate of z score change outliers (i.e., elevated atrophy), which may provide further evidence for a hippocampal‐sparing subtype.36, 37, 38, 39. This evidence concerns the gene APOE and Alzheimer disease.