The complement C3‐C3aR pathway mediates microglia‐astrocyte interactions following status epilepticus (SE)41, 42 reported that C4B (but not C3)‐deficient mice exhibited increased susceptibility to seizures induced by PTZ and failed to upregulate the expression of multiple immediate early genes (IEGs) including Egrs1‐4 and c‐Fos. Here, C4B is linked to status epilepticus.