Up‐regulation of TRPV1: TRPV1 is known to mediate skin reactivity, flushing, burning, itching, and stinging sensations when stimulated.18 TRPV1 expression is upregulated in subjects with SS, and it correlates with the intensity of the symptoms.19 Keratinocytes express TRPV1/TRPV4 which is coupled to pruritus receptors, possibly to amplify and optimize sensory perception17. Here, TRPV4 is linked to synovial sarcoma.