Ultimately, our research discovered that ITIH1, whose expression was regulated by both TGF‐β stimulation and m6A modification, inhibited HCC metastasis by inhibiting the integrin/FAK signaling pathway, and we preliminarily verified the effectiveness of the application of recombinant ITIH1 to suppress HCC metastasis (Figure 7G). This evidence concerns the gene PTK2 and hepatocellular carcinoma.