Integrin signaling is involved in many cellular functions, such as adhesion, migration, and oncogenic transformation.[27, 28] Aberrant activation of integrin signaling has been linked with the malignant features of HCC.[29] One of the most important downstream effectors is focal adhesion kinase (FAK), which has been shown to drive HCC progression and correlate with a poor clinical outcome. This evidence concerns the gene PTK2 and hepatocellular carcinoma.