Extracellular matrix (ECM) proteins can function as ligands and regulators of the integrin/FAK signaling pathway and are thus involved in cancer progression.[31] Inter‐alpha (globulin) inhibitor H1 (ITIH1) is a member of a heavy chain family, whose currently known function of the heavy chains is to provide a covalent linkage to hyaluronic acid, which is a major component of the ECM.[32] In this study, we explored the mechanisms by which ITIH1 regulates HCC development and tested its therapeutic potential in HCC in mice. The gene discussed is PTK2; the disease is hepatocellular carcinoma.