Notably, SHP2 appears to be involved in female infertility[30] and endometriosis,[31] while also playing essential roles in the physiological function of embryo implantation and stromal decidualization.[32] Collectively, these reports indicate that SHP2 expression may respond to estrogen and that SHP2 may have various functions in different estrogen‐related disorders. Here, PTPN11 is linked to female infertility.