In the present study, the fusion with human IgG1 Fc in Nb‐TriTE enhanced the secretion of GM‐CSF, MCP‐1, eotaxin, and pro‐inflammatory cytokines, while reducing immunosuppressive cytokine IL‐10 secreting from PBMCs when challenged with tumor cells (Figure S8, Supporting Information). The gene discussed is CSF2; the disease is neoplasm.