In bone metastases (Waning et al., 2015) and osteogenesis imperfecta (Grafe et al., 2014), excessive TGF‐β signaling is coupled with oxidative stress or upregulation of senescence markers, respectively, which may ultimately converge on the same pathways and downstream effects on cell functions (Grafe et al., 2014; Waning et al., 2015). The gene discussed is TGFB1; the disease is osteogenesis imperfecta.