Such thesis is supported by findings of markers of astroglial damage, such as S100 β and glial fibrillar acid protein (GFAP), along with alterations in AQP-4 expression [97, 98] and with alterations in choroid plexus (CP) morphology [99] found both in dementia and in depressed patients presenting cognitive alteration [100-102]. The gene discussed is AQP4; the disease is dementia.