AQP4 and bipolar disorder: Despite a clear correlation has not been demonstrated yet, data on anxious behavior after fragmented or deprived sleep, and manic-like behaviors that were induced in mice by sleep fragmentation, shed light on potential involvement in bipolar disorder [115, 116], which would be consistent with the expression of markers of astroglial damage [117] and AQP-4 altered gene expression in bipolar disorder individuals [98].