EPAS1 and atherosclerosis: However, EPAS1 is known to promote vascularization by stabilizing newly formed microvascular networks and by driving arteriogenesis.12–15 EPAS1 regulates several other physiological processes, including embryogenesis, erythropoiesis, tumorigenesis, and liver metabolism.16–19 However, the potential role of EPAS1 in arterial homeostasis, EC mechanical responses, and atherosclerosis remains unclear.