The potential role of hyperlipidemia in EPAS1 suppression was analyzed by treatment of obese mice with sulforaphane, a compound from broccoli and other cruciferous vegetables that is known to modify lipid profiles32 and protect endothelium.33 Sulforaphane treatment significantly reduced plasma levels of TGs in obese mice exposed to the HFD (Figure 4A), whereas glycemia (Figure 4B), body weight (Figure S5A), and plasma levels of total cholesterol (Figure S5B), HDL, and LDL/VLDL (Figure S5C) were not significantly altered. The gene discussed is EPAS1; the disease is hyperlipidemia.