The first weighted binomial model indicated that unspecific versus specific binding of the apoE4 protein (= apoE4 stats 1, 0) is associated with increased odds of global cognitive impairment (odds ratio [OR]: 1.57, 95% confidence interval [CI] = 1.09–2.27, p < 0.05, model 1a), particularly in the oldest age group (OR: 1.04, 95% CI = 1.00–1.09, p < 0.05, model 1b and Figure 2A), consistent with the literature on APOE ε4 genotype and late‐onset AD.41 Here, APOE is linked to Alzheimer disease.