C3 was indicated a protective factor for the cases (OR <1, p < 0.05) and anti-CCP, IL-1ß, IL-5, IL-6, IL-17, IL-12p70, TNF-α, and INFγ were risk factors for pSS-ILD occurrence (OR >1, p < 0.05). Here, IL17A is linked to interstitial lung disease.