SEPTIN9 and colorectal carcinoma: Non-invasive CRC screening methods have the advantages of painless, simple and fast, such as guaiac-based fecal occult blood tests (gFOBTs), fecal immunochemical tests (FITs), multi-target stool DNA (mt-sDNA) test, and serology detection of methylated septin 9 gene (Ladabaum et al., 2020).