The predicted KEGG pathways in metastatic CRC patients were different from CRC patients without metastasis (Figure 7E), and notably different KEGG pathways were enriched in CRC with metastasis group, such as ABC transporters, ribosome, glycolysis, pyrimidine metabolism, aminoacyl-tRNA biosynthesis (Figure 7F). The gene discussed is ABCG2; the disease is colorectal carcinoma.