It is worthwhile noting that seven of them have the highest citation time between 2020 and 2022, namely “gut-liver axis” (2019–2022), “bile acid” (2020–2022), “gut microbiota” (2020–2022), “gut microbiome” (2020–2022), “short-chain fatty acid” (2020–2022), “cardiovascular disease” (2020–2022), “colorectal cancer” (2020–2022), and “farnesoid x receptor” (2020–2022), indicating that these terms are widely investigated and recognized at present time. Here, NR1H4 is linked to colorectal cancer.